Four-Year-Old Dies of Medicine Overdose, Murder Suspected

Child's overdose death raises questions By DENISE LAVOIE, Associated Press Writer
Fri Mar 23, 2:58 PM ET



HULL, Mass. - In the final months of Rebecca Riley's life, a school nurse said the little girl was so weak she was like a "floppy doll."

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The preschool principal had to help Rebecca off the bus because the 4-year-old was shaking so badly.

And a pharmacist complained that Rebecca's mother kept coming up with excuses for why her daughter needed more and more medication.

None of their concerns was enough to save Rebecca.

Rebecca — who had been diagnosed with attention deficit hyperactivity and bipolar disorder, or what used to be called manic depression — died Dec. 13 of an overdose of prescribed drugs, and her parents have been arrested on murder charges, accused of intentionally overmedicating their daughter to keep her quiet and out of their hair.

Interviews and a review of court documents by The Associated Press make it clear that many of those who were supposed to protect Rebecca — teachers, social workers, other professionals — suspected something was wrong, but never went quite far enough.

But the tragic case is more than a story about one child. It raises troubling, larger questions about the state of child psychiatry, namely: Can children as young as Rebecca be accurately diagnosed with mental illnesses? Are rambunctious youngsters being medicated for their parents' convenience? And should children so young be prescribed powerful psychotropic drugs meant for adults?

Dispensing drugs to children diagnosed with mood or behavior problems is "the easiest thing to do, but it's not always the best thing to do," said Dr. Jon McClellan, medical director of the Child Study and Treatment Center in Lakewood, Wash. "At some level, I would hope that you'd also be teaching kids ways to control their behavior."

According to the medical examiner, Rebecca died of a combination of Clonidine, a blood pressure medication Rebecca had been prescribed for ADHD; Depakote, an antiseizure and mood-stabilizing drug prescribed for the little girl's bipolar disorder; a cough suppressant; and an antihistamine. The amount of Clonidine alone in Rebecca's system was enough to be fatal, the medical examiner said.

The two brand-name prescription drugs are approved by the Food and Drug Administration for use in adults only, though doctors can legally prescribe them to youngsters and do so frequently.

Rebecca's parents, Michael and Carolyn Riley, say they were only following doctor's orders. Rebecca, they told police, had been diagnosed when she was just 2 1/2, and Rebecca's psychiatrist prescribed the same potent drugs that had been prescribed for her older brother and sister when she diagnosed them with the same illnesses several years earlier.

But Rebecca's teachers, the school nurse and her therapist all told police they never saw behavior in Rebecca that fit her diagnoses, such as aggression, sharp mood swings or hyperactivity.

Prosecutors say the Rileys intentionally tried to quiet their daughter with high doses of Clonidine. Relatives told police the Rileys called Clonidine the "happy medicine" and the "sleep medicine."

Through their attorneys, Michael Riley, 34, and Carolyn Riley, 32, have accused Rebecca's psychiatrist, Dr. Kayoko Kifuji, of over-prescribing medication.

Kifuji did not return calls for comment and declined to be interviewed. But Kifuji has vehemently denied any role in Rebecca's death. She has agreed to a suspension of her license while the state's medical board investigates.

Kifuji told police Rebecca had been her patient since August 2004, when she was 2. She said she based her diagnoses of ADHD and bipolar disorder on the family's mental health history, as described by Carolyn Riley, and Rebecca's behavior, as described by Carolyn and briefly observed by her during office visits.

Kifuji told police she became alarmed in October 2005 when Carolyn Riley told her she had increased Rebecca's nighttime dose of Clonidine from 2 to 2 1/2 tablets, and warned Carolyn the increased dose could kill Rebecca.

But Carolyn told investigators Kifuji told her she could give Rebecca and her sister extra Clonidine at night to help them sleep.

Tufts-New England Medical Center, where Kifuji worked, issued a statement supporting Kifuji, saying her care of Rebecca "was appropriate and within responsible professional standards."

In the months leading up to Rebecca's death, others noticed there was something wrong.

Teachers and staff members at the Johnson Early Childhood Center in Weymouth, about 20 miles south of Boston, say they called Rebecca's mother repeatedly to tell her that Rebecca was "out of it," but her mother said the girl was tired because she wasn't sleeping well.

A neighbor who lived next door to the family in the last month of Rebecca's life said Rebecca and her siblings seemed listless.

"They looked like little robots. They looked very lethargic," Phyllis Lipton said. "I said, `Wow, they don't look right,' but who knew?"

Pharmacists at Walgreens in Weymouth called Kifuji twice to complain that Carolyn Riley was asking for more Clonidine, even though her prescription was not due to be refilled yet, according to state police.

Once, Riley said she had lost a bottle of pills, and another time, she said water had gotten into her prescription bottle and ruined the pills, according to police.

Kifuji authorized refills, but after the second incident, she began prescribing Clonidine in 10-day refills instead of 30-day supplies, investigators said.

On Aug. 16, a prescription for 35 Clonidine tablets — a 10-day supply — was filled at Walgreens, even though the Rileys had obtained a 10-day refill only the day before, investigators said.

Walgreens spokeswoman Tiffani Bruce said: "The scrip was filled as written, as it was prescribed by the doctor, and all the appropriate information on the medications was given to the family."

After Rebecca's death, police found only seven Clonidine tablets in the family's medicine tray; the pharmacist said there should have been 75. All together, prosecutors say, Carolyn Riley got 200 more pills in one year than she should have.

The Rileys' lawyers call them unsophisticated people who did not question their children's doctors.

Both were unemployed; they collected welfare and disabilty benefits and lived in subsidized housing. Michael Riley, who is also awaiting trial on charges of molesting a stepdaughter in 2005, claimed to suffer from bipolar disorder and a rage disorder; his wife told police she suffered from depression and anxiety.

"They are not the sort of people who go on the Internet and look on WebMD. These are the sort of people who, when they go to a doctor, the doctor is God and they do what the doctor says," said John Darrell, Michael's lawyer.

Carolyn's lawyer, Michael Bourbeau, said that because the Rileys' three children were all taking Clonidine, Rebecca's prescription may have come up short at times when her siblings were given some of her pills. And some of the pills may have been lost when they were split in half, he said.

In July, after a therapist filed a complaint with the state Department of Social Services, social workers met with the family's doctors and other medical professionals and were assured that the medications Rebecca was taking were within medical guidelines.

"There were lots of medical eyes on this case and none of them seemed to say there was an issue of over-medication in this case," said Social Services Commissioner Harry Spence, who has come under fire for the agency's handling of the case.

Still, there were lingering concerns. When social workers tried to make a home visit in November, Carolyn "resisted and evaded," Spence said. Weeks later, workers resolved to make a surprise check, but Rebecca died the very next day, before they could visit.

Rebecca was found dead on the floor of her parents' bedroom wearing only a pink pull-up diaper and gold-stud earrings, on top of a pile of clothes, magazines and a stuffed brown bear.

Rebecca's uncle, James McGonnell, and his girlfriend, Kelly Williams, who lived with the Rileys, told police that the Rileys would put their kids to bed as early as 5 p.m. Rebecca, they said, often slept through the day and got up only to eat.

When Michael Riley decided the kids were "acting up," he told Carolyn to give them pills, McGonnell and Williams told police.

According to McGonnell and Williams, Rebecca spent the last days of her life wandering around the house, sick and disoriented. But the Rileys told police they were not alarmed. "It was just a cold," Carolyn repeatedly said during police interviews.

The medical examiner said Rebecca died a slow and painful death. She said the overdose of Clonidine caused her organs to shut down, filling her lungs with fluid and causing congestive heart failure.

Williams told police that the night before she died, Rebecca was pale and seemed "out of it." At one point, the little girl knocked weakly on her parents' bedroom door and softly called for her mommy, but Michael Riley opened the door a crack and yelled at her to go back to her room, Williams said.

Later that night, McGonnell told police, he heard someone struggling to breathe and found Rebecca gurgling as if something was stuck in her throat. McGonnell told police he wiped vomit from his niece's face, then kicked in the door to her parents' room and yelled at the Rileys to take Rebecca to the emergency room.

Instead, Carolyn Riley said, she gave her daughter a half-tablet of Clonidine.

Carolyn's mother, Valerie Berio, said that when she visited the kids the night of Dec. 11, Rebecca seemed congested but not seriously ill. In a photograph Berio said she took that night, Rebecca is smiling slightly as her mother holds a new green velvet dress in front of her.

Berio said that shows that her daughter and son-in-law could not have known how sick Rebecca was.

Rebecca's death has inflamed a long-running debate in psychiatry. Some psychiatrists believe bipolar disorder, which was traditionally diagnosed in adolescence or early adulthood, has become a trendy diagnosis in young children.

"As a clinician, I can tell you it's just very difficult to say whether someone is just throwing tantrums or has bipolar disorder," said Dr. Oscar B. Bukstein, a child psychiatrist and associate professor at the University of Pittsburgh.

A study of mentally ill children discharged from community hospitals, published in January in the Archives of General Psychiatry, found the proportion of children diagnosed with bipolar disorders jumped from 2.9 percent in 1990 to 15.1 percent in 2000.

A report released by the Centers for Disease Control and Prevention in 2002 estimated that about 7 percent of elementary school-age children — or approximately 1.6 million youngsters ages 6 to 11 — have been diagnosed with ADHD.

The annual number of U.S. children prescribed anti-psychotic drugs jumped fivefold between 1995 and 2002, to an estimated 2.5 million, according to a study published last year by researchers at Vanderbilt Children's Hospital in Nashville, Tenn.

Some child psychiatrists say bipolar disorder may have been under-diagnosed in children for years, partly because several key symptoms are also symptoms of ADHD, including hyperactivity, distractibility and talkativeness.

Dr. Janet Wozniak, director of the Pediatric Bipolar Disorder Research Program at Massachusetts General Hospital, said early diagnosis and treatment are critical because the illness can cause social and academic problems, and lead to drug abuse, crime and suicide.

"What's commonly overlooked when considering diagnosing and treating children at such an early age is the risk of not treating and not intervening," Wozniak said.

(Corrects by deleting reference to photo being taken 18 hours earlier.)

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Pet Food Contaminated with Rat Poison, Cancer Drug

Rat poison found in tainted pet food By MARK JOHNSON, Associated Press Writer
46 minutes ago



ALBANY, N.Y. - Rat poison was found in pet food blamed for the deaths of at least 17 cats and dogs, but scientists said Friday they still don't know how it got there and predicted more animal deaths would be linked to it.

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After the announcement, the company that produced the food expanded its recall to include all 95 brands of the "cuts and gravy" style food, regardless of when they were produced. The company also said it would take responsibility for pet medical expenses incurred as a result of the food.

The substance in the food was identified as aminopterin, a cancer drug that once was used to induce abortions in the United States and is still used to kill rats in some other countries, state Agriculture Commissioner Patrick Hooker said.

The federal government prohibits using aminopterin for killing rodents in the U.S. State officials would not speculate on how the poison got into the pet food, but said no criminal investigations had been launched.

The pet deaths led to a recall of 60 million cans and pouches of dog and cat food produced by Menu Foods and sold throughout North America under 95 brand names. Some pets that ate the recalled brands suffered kidney failure, and the company has confirmed the deaths of 15 cats and two dogs.

The latest death, a Yorkshire terrier named Pebbles, occurred Thursday. The dog died of kidney failure after eating some of the food. Her owner, Jeff Kerner, said he was contacting an attorney because he wanted to prevent another pet tragedy.

"Before they put this stuff in the bags, there should be some kind of test," said Kerner, of Sherman Oaks, Calif. "I can't just let it go. Even if they just change the law."

The company expanded the recall — which initially covered only cans and pouches of food packaged from Dec. 3 through March 6 — after the FDA alerted it that some products remained on store shelves.

There is no risk to pet owners from handling the food, officials said.

The Food and Drug Administration has said the investigation into the pet deaths was focused on wheat gluten in the food. The gluten itself would not cause kidney failure, but it could have been contaminated, the FDA said.

Paul Henderson, chief executive of Ontario, Canada-based Menu Foods, confirmed Friday that the wheat gluten was purchased from China.

Bob Rosenberg, senior vice president of government affairs for the National Pest Management Association, said it would be unusual for the wheat to be tainted.

"It would make no sense to spray a crop itself with rodenticide," Rosenberg said, adding that grain shippers typically put bait stations around the perimeter of their storage facilities.

Scientists at the New York State Animal Health Diagnostic Center at Cornell University and at the New York State Food Laboratory tested three cat food samples provided by the manufacturer and found aminopterin in two of them. The two labs are part of a network created after the Sept. 11 terrorist attacks to keep the nation's animals and food supply safe.

"Any amount of this product is too much in food," Hooker said.

Aminopterin is highly toxic in high doses. It inhibits the growth of malignant cells and suppresses the immune system. In dogs and cats, the amount of aminopterin found — 40 parts per million — can cause kidney failure, according to Bruce Akey, director of Cornell's diagnostic center.

"It's there in substantial amounts," Akey said.

Donald Smith, dean of Cornell's veterinary school, said he expected the number of pet deaths to increase. "Based on what we've heard the last couple days, 16 is a low number," Smith said.

Aminopterin is no longer marketed as a cancer drug, but is still used in research, said Andre Rosowsky, a chemist with the Dana Farber Cancer Institute in Boston.

Rosowsky speculated that the substance would not show up in pet food "unless somebody put it there."

Henderson said Menu Foods does not believe the food was tampered with because the recalled food came from two different plants, one in Kansas, one in New Jersey. Menu continues to produce food at the two plants.

The company, already facing lawsuits, said Friday it is testing all the ingredients that go into the food.

"We have a lot of work to do, and we are eager to get back to it," Henderson said. "This is a highly unusual substance."

When asked whether there would compensation for medical bills for sick pets, Henderson said "to the extent that we identify that the cause of any expenses incurred are related to the food, Menu will take responsibility for that."

A complete list of the recalled products along with product codes, descriptions and production dates was posted online by Menu Foods and is available at http://tinyurl.com/2pn6mm. The company also designated two phone numbers that pet owners could call for information: (866) 463-6738 and (866) 895-2708.

___

Associated Press writers Andrew Bridges in Washington, Michael Virtanen in Albany and Solvej Schou in Los Angeles contributed to this report.

___

On the Net:

FDA pet food recall information: http://www.fda.gov/oc/opacom/hottopics/petfood.html

Menu Foods: http://tinyurl.com/2pn6mm

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Text Messages Gets Pothead Teacher Caught

Text messages land teacher in hot water
Sat Feb 24, 6:24 AM ET
MURRAY, Ky. - A middle school teacher trying to buy pot was arrested after she sent text messages to state trooper instead of a dealer, police said.
Trooper Trevor Pervine was at dinner with his wife and parents celebrating a birthday when his phone started buzzing with messages about a marijuana purchase.
At first, Pervine thought the messages were from friends playing a joke, Kentucky State Police spokesman Barry Meadows said. But a couple of phone calls put that idea to rest, and Pervine responded to set up a meeting, Meadows said.
Authorities say Ann Greenfield, 34, arrived at the meeting point and found Pervine and other law enforcement officers waiting for her.
"She learned her lesson. Program your dealers into your phone," Meadows said.
Greenfield, a teacher at Murray Middle School, was charged with conspiracy to traffic in controlled substances within 1,000 feet of a school, possession of marijuana and possession of drug paraphernalia, Meadows said.
She was suspended with pay pending results of an investigation, the Murray Independent School District said in a statement posted Friday on the district's Web site. A message seeking comment left at a listing for an Ann Greenfield in Murray, Ky. was not returned.http://news.yahoo.com/s/ap/20070224/ap_on_fe_st/text_message_arrest